Endocrinology and Complications of Diabetes

Genetic Diabetes

There are a number of rare cases of diabetes that rise due to an irregularity in a single gene (known as monogenic methods of diabetes).These contain maturity onset diabetes of the young (MODY), Donohue disorder, and Rabson–Mendenhall disorder, among others. Maturity beginning diabetes of the young constitutes 1–5% of all cases of diabetes in young people.

Type 2 diabetes does not have a clear form of inheritance, while many affected persons have at least one close family member, such as a parent or sibling, with the syndrome. The risk of emerging type 2 diabetes increases with the number of affected family members.

The genetic transformations that cause diabetes contain the proteins responsible for insulin production or the ability of the body to use insulin. Mutations cause the proteins to function incorrectly. Genetic analysis can identify these modifications in certain cases, but the usefulness of the information they provide differs.

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